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AAAS ScienceMag.org Search Search X Advanced Search Contents News Careers Journals Menu Cover story: Prolactin provokes pain responses Selective opioid-induced hyperalgesia in female mice results from an imbalance of prolactin receptor isoforms Frank Porreca A global immune landscape Anemia status and geography affect immune development in African children David Mack/Science Source Codependent deconstruction Osteoclast-derived matrix metalloproteinases MMP9 and MMP14 codependently drive bone resorption Zhu et al ./ Contents 05 February 2020 Vol 12, Issue 529 Research Articles The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females By Yanxia Chen , Aubin Moutal , Edita Navratilova , Caroline Kopruszinski , Xu Yue , Megumi Ikegami , Michele Chow , Iori Kanazawa , Shreya Sai Bellampalli , Jennifer Xie , Amol Patwardhan , Kenner Rice , Howard Fields , Armen Akopian , Volker Neugebauer , David Dodick , Rajesh Khanna , Frank Porreca 05 Feb 2020 Full Access Restricted Access Female selective nociceptor sensitization and opioid-induced hyperalgesia result from an imbalance of prolactin receptor isoforms. Editor’s Summary Abstract Full Text PDF Supplementary Materials Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases By Lingxin Zhu , Yi Tang , Xiao-Yan Li , Evan T. Keller , Jingwen Yang , Jung-Sun Cho , Tamar Y. Feinberg , Stephen J. Weiss 05 Feb 2020 Full Access Restricted Access Independent of cathepsin K, the osteoclast-derived matrix metalloproteinases MMP9 and MMP14 codependently drive bone resorption. Editor’s Summary Abstract Full Text PDF Supplementary Materials Distinct immune phenotypes in infants developing asthma during childhood By Anna Hammerich Thysen , Johannes Waage , Jeppe Madura Larsen , Morten Arendt Rasmussen , Jakob Stokholm , Bo Chawes , Nadia Rahman Fink , Tine Marie Pedersen , Helene Wolsk , Sunna Thorsteinsdottir , Thomas Litman , Harald Renz , Klaus Bønnelykke , Hans Bisgaard , Susanne Brix 05 Feb 2020 Full Access Restricted Access Early immune responses are associated with different asthma trajectories in children. Editor’s Summary Abstract Full Text PDF Supplementary Materials APOE genotype regulates pathology and disease progression in synucleinopathy By Albert A. Davis , Casey E. Inman , Zachary M. Wargel , Umber Dube , Brittany M. Freeberg , Alexander Galluppi , Jessica N. Haines , Dhruva D. Dhavale , Rebecca Miller , Fahim A. Choudhury , Patrick M. Sullivan , Carlos Cruchaga , Joel S. Perlmutter , Jason D. Ulrich , Bruno A. Benitez , Paul T. Kotzbauer , David M. Holtzman 05 Feb 2020 Full Access Restricted Access APOE genotype regulates disease development in mouse models of α-synucleinopathy and affects cognition in patients with Parkinson’s disease. Editor’s Summary Abstract Full Text PDF Supplementary Materials APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid By Na Zhao , Olivia N. Attrebi , Yingxue Ren , Wenhui Qiao , Berkiye Sonustun , Yuka A. Martens , Axel D. Meneses , Fuyao Li , Francis Shue , Jiaying Zheng , Alexandra J. Van Ingelgom , Mary D. Davis , Aishe Kurti , Joshua A. Knight , Cynthia Linares , Yixing Chen , Marion Delenclos , Chia-Chen Liu , John D. Fryer , Yan W. Asmann , Pamela J. McLean , Dennis W. Dickson , Owen A. Ross , Guojun Bu 05 Feb 2020 Full Access Restricted Access APOE4 exacerbates α-synuclein pathology in a synucleinopathy mouse model, and APOE4 genotype associates with increased α-synuclein pathology in humans. Editor’s Summary Abstract Full Text PDF Supplementary Materials Research Resource Immune system development varies according to age, location, and anemia in African children By Danika L. Hill , Edward J. Carr , Tobias Rutishauser , Gemma Moncunill , Joseph J. Campo , Silvia Innocentin , Maxmillian Mpina , Augusto Nhabomba , Anneth Tumbo , Chenjerai Jairoce , Henriëtte A. Moll , Menno C. van Zelm , Carlota Dobaño , Claudia Daubenberger , Michelle A. Linterman 05 Feb 2020 Full Access Restricted Access The composition and function of the immune system in African children is linked to age, location, and anemia. Editor’s Summary Abstract Full Text PDF Supplementary Materials Editors’ Choice Livening up pertussis vaccine development By Michelle Boyle 05 Feb 2020 Full Access Restricted Access Vaccination with a B. pertussis live attenuated vaccine induces a beneficial T H 1 cell bias and broadly targeting functional antibodies in humans. Abstract Full Text Undressing drug reactions, one cell at a time By Rajan P. Kulkarni 05 Feb 2020 Full Access Restricted Access Single-cell transcriptomic analysis allowed successful treatment of a patient with refractory severe drug-induced hypersensitivity syndrome. Abstract Full Text Let’s switch on AAV! By Giuseppe Ronzitti 05 Feb 2020 Full Access Restricted Access RNA switches expand the reach of AAV vectors. Abstract Full Text More From Current Table of Contents First Release Papers Archive In the Pipeline About Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Get the eTOC Alert Submit Free Sample Articles About The Cover ONLINE COVER Sex-Linked Differences in Pain Pathways. This image shows colocalization (yellow) of the prolactin receptor (green) with the mu opioid receptor (red) in a dorsal root ganglion from a female mouse. Males and females experience pain differently. To disentangle the mechanisms mediating this difference, Chen et al . studied opioid-induced hyperalgesia (OIH) in male and female mice. In female animals, OIH was mediated by decreased expression of the prolactin receptor isoform L and increased activation of the isoform S. Overexpression of prolactin receptor isoform L or inhibition of circulating prolactin prevented OIH in female mice. Targeting prolactin signaling may be effective for treating OIH in women. 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